After a car crash sends repressed cartoonist Stu Miley (Fraser) into a coma, he and the mischievous Monkeybone, his hilariously horny alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu\'s body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!
A ticking-time-bomb insomniac and a slippery soap salesman channel primal male aggression into a shocking new form of therapy. Their concept catches on, with underground \"fight clubs\" forming in every town, until an eccentric gets in the way and ignites an out-of-control spiral toward oblivion.
In honor of his birthday, San Francisco banker Nicholas Van Orton, a financial genius and a coldhearted loner, receives an unusual present from his younger brother, Conrad -- a gift certificate to play a unique kind of game. In nearly a nanosecond, Nicholas finds himself consumed by a dangerous set of ever-changing rules, unable to distinguish where the charade ends and reality begins.