Tom, greeting-card writer and hopeless romantic, is caught completely off-guard when his girlfriend, Summer, suddenly dumps him. He reflects on their 500 days together to try to figure out where their love affair went sour, and in doing so, Tom rediscovers his true passions in life.
Following a ridiculously awful flight that leads to his pet\'s death, Nashawn Wade files a lawsuit against the airline, and wins a multimillion-dollar settlement. Determined to create a better flying experience, Nashawn starts his own airline, one that caters to an African-American clientele. Going into business with a tricked-out plane piloted by the smooth Capt. Mack, the airline hits a snag when it has to deal with the family of Elvis Hunkee.
The hilarity begins when professor Sherman Klump finds romance with fellow DNA specialist, Denise Gaines, and discovers a brilliant formula that reverses aging. But Sherman\'s thin and obnoxious alter ego, Buddy Love, wants out...and a big piece of the action. And when Buddy gets loose, things get seriously nutty.