With the city reeling from Maladie's opera debut, Mundi takes a personal stake in tracking her down, while Amalia launches an investigation of her own. Meanwhile, the charitable Lavinia Bidlow seeks to destigmatize the Touched at a society event, Hugo Swann enlists Lavinia’s younger brother Augie to help monetize his illicit enterprise, and a deranged doctor conducts a series of experiments.
When professor Fiona Ryan’s car window is smashed following a series of mysterious notes, Nolan volunteers to guard her house overnight. Lucy notices that Tim is being much nicer to his new boot than he was with her and she does not like it.
Elizabeth is distraught over the reveal of Nathan's secret. Everyone helps a couple prepare for their wedding. The bachelor and bachelorette parties stir up mixed emotions from the guests. A mysterious businessman arrives in town.
Mac and Desi travel with Bozer to his childhood home when his aunt dies in a tragic accident, however, they soon discover she may have been murdered for trying to expose the city’s contaminated water supply. Also, Riley, Matty and Russ continue to follow leads on their nano-trackers investigation.
After three months in hiding from Chin Gigante and the Italians, Bumpy Johnson takes action to lift the sanctions off his head. By forging new alliances with European suppliers, Bumpy aims to reunite with his family safely back in Harlem.
After seeing Holly in the ICU, Jackie reckons with the destructive consequences of his actions, as Rickey Townsend prepares to testify against Decourcy. With violence intensifying between the Copeland Crew and the Braxton Boys, Decourcy, Anton and Siobhan face off in the interrogation room. Grace, left reflecting on her role as a mother and leader in the community, makes an unfortunate miscalculation. And back at the Rohr house, Jenny makes fast friends with the mysterious woman from Belfast.
A psychic hires Magnum and Higgins to prevent a murder she claims to have foreseen. Also, Katsumoto questions Kumu when her information is found on recovered stolen jewels that once belonged to the infamous Imelda Marcos, and Higgins struggles with whether or not to tell Ethan the truth about her past.
Walker and Captain James investigate a high stakes poker game where one of the players may have information on Emily’s killer. The night takes a turn when Geri shows up to join the game. Meanwhile, Micki takes August and Stella on an unusual adventure.
Business becomes personal for Frank and his 1 Police Plaza team when Baker is assaulted on the street, as well as for Erin, when she asks her ex-husband, Jack Boyle, to represent a defendant she’s prosecuting. Also, Eddie wonders if she’s being too stubborn after she publicly undermines one of Jamie’s decisions at work, and Danny and Baez investigate the attempted murder of a couple with huge secrets.
With the help of best friend, Doofus, Frank is determined to win back his ex, Áine, by learning MMA, and playing his first gig in years — her grandmother’s funeral. Will Frank succeed in impressing Áine, or will it be a disaster?
Marine veteran Riley, home at last after serving in Afghanistan, is happily reunited with his friend Awalmir, who goes by Al, the interpreter with his unit, after a long struggle to get him a visa to travel to the United States from Afghanistan.
While in pursuit of criminals, Michaela is sidelined by devastating news. Ben teams up with a gifted 828er to aid a young teen. As Grace confronts ancient family wounds, Olive explores ancient mythology in hopes of helping all the passengers.
Maya, Jack, Vic, Travis and Sullivan respond to a burn call at an ice rink. Meanwhile, a pregnant woman and her husband seek out the station for help; and Maya and Carina have a difficult conversation.
Sean Sr. copes with ill feelings after being benched on his hockey team right before the South Side Championship game. Meanwhile, Ann has her first session as a psychologist and the family sees more of her mentor, Grace.
After capturing a new monster at the school, Hope and the Super Squad learn some terrifying news about one of their own. A surprise visit from Lizzie gives Josie some much-needed courage. MG and Ethan team up to help others.
Maggie is preoccupied with Winston while trying to treat a patient wounded in the Seattle protests. Meanwhile, Levi is tested by an emergency, and the doctors struggle to treat a patient who doesn't believe in COVID.
Mike and Vanessa help Mandy and Kyle with their estate planning, but are disappointed with whom they plan to appoint as Sarah's legal guardian. Meanwhile, Jen begins working at OutdoorMan and takes advice from Chuck a tad too seriously.
Pennsylvania, 1987: When Karen asks to come over to his house for dinner, Dwayne panics - he's been lying to her about being rich. Meanwhile, in 2032 Candidate Johnson tackles an emerging public relations crisis.
Mika is determined to use the show's annual "Wednesday's Gal" wedding segment to generate desperately needed advertising revenue for the station. With love in the air, Kenan contemplates his romantic future.
When world-famous Europol profiler Simon Hoxley shows up in New York and claims that Major Crimes' current case is connected to the discovery of Endicott's body overseas, Bright fears he and Ainsley's secret is about to be exposed. Meanwhile, Martin gets to know Dr. Vivian Capshaw.
It's National HIV Testing Day and Max has offered free care to all HIV+ patients who come to New Amsterdam. Bloom and Reynolds butt heads over their opposing bedside manners. Iggy eagerly awaits the return of a friend. Sharpe discovers that she may need more hands on with her niece.
The Hayworth family is invited to the wedding of longtime family friend Spags. When Connor enlists Tom's help to write and re-write a wedding toast, things take an unexpected turn between the brothers. Sarah realizes Denise is upset they never had a real wedding, while Marina meticulously plans her drinking schedule for a night out without the kids.
Callie juggles the murder case and her feelings towards Gael. Mariana helps Alice take control of her life. Meanwhile, Davia struggles with her feelings towards Dennis and Matt. Gael faces an ethical dilemma regarding his boss.
After realizing there may be trouble in lovers' paradise for Erica and Geoff, Beverly involves herself in their relationship as well as Barry and Joanne's to make sure everyone stays together. Meanwhile, Adam and Brea are cast opposite of each other in the school play, but their excitement for one another's success grows dim when one starts to outshine the other onstage.
When Barry and Joanne crash Erica and Geoff's peaceful weekend camping trip, they end up in a competition to see who is the better couple, causing some unexpected shifts in relationships. After learning that Brea thinks Adam has an easy, privileged life, Adam seeks to prove her wrong by getting a job but quickly learns she might be right.
Realizing she and Diane share a surprising connection, Hazel goes out of her way to coordinate a special anniversary dinner for her father and his partner. Things get personal during Herb’s check-in with Judiff, prompting him to share his deepest secret. Byron delivers his first public press conference in years and gains surprising clarity about his marriage.
When Lane's judgmental mom comes to town, Lane tries to hide anything that she may disapprove of; Freddie attempts to hide his professional success to make Jackie feel better about her current difficulties.